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Istesso

Develops oral mitochondrial Complex I modulator medicines to restore tissue repair; lead candidate leramistat is in Phase 2

London, United KingdomFounded 2017istesso.co.ukWebsite technologies

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Highlights

  • New on EvolcAdded 2026-10-28

About Istesso

Istesso develops oral mitochondrial Complex I modulators (MCMs), systemic medicines intended to restore the capacity of tissues to sense stress, adapt and repair. The company describes its work as an adaptive repair platform.

Its lead programme, leramistat, is in Phase 2. In June 2026 Istesso announced the start of a Phase 2 clinical trial of leramistat in sarcopenia, the age-related loss of skeletal muscle mass and strength.

Istesso is headquartered in London, UK, and was founded in 2017. Lisa Patel is Chief Executive Officer and co-founder, and Sam Williams is Chairman and co-founder. The team page also lists a head of translational sciences, finance and operations and project management staff, a board of non-executive directors and a group of consultant advisers.

Product: Oral mitochondrial Complex I modulators (MCMs) for restoring tissue repair; lead candidate leramistat is in Phase 2 clinical development.

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