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C4X Discovery Holdings

Discovers small molecule drugs for immuno-inflammatory diseases, with partnered programmes at Sanofi and AstraZeneca

Leeds, United KingdomFounded 2014c4xdiscovery.comWebsite technologies

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  • New on EvolcAdded 2026-10-28

About C4X Discovery Holdings

C4X Discovery is a drug discovery company focused on small molecule medicines for immuno-inflammatory diseases. Its Conformetrix platform supports structural drug design using measured experimental data, and its PatientSeek platform uses genetics-led patient stratification to estimate a patient's likelihood of response to therapy.

Its internal discovery portfolio is advancing toward clinical trials, with one programme at pre-clinical candidate selection. Two programmes are commercially partnered with Sanofi and AstraZeneca, and one clinical-stage candidate has been acquired by Indivior. Partnering agreements include milestone payments, as in a September 2026 milestone under an NRF2 exclusive worldwide licence.

The company is headquartered in Leeds, UK, and was founded in 2014. Emma Blaney has been interim CEO since January 2025, and Charles Blundell is CTO. In September 2026 it reported in vivo proof of concept for its PAD4 inhibitor programme.

Product: Conformetrix structural drug design platform, PatientSeek genetics-led patient stratification tool, and small molecule drug candidates in immuno-inflammation.

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